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It’s not a global emergency, but the public is also apparently impatient with science’s progress on providing practical advice about the human microbiome — the collection of bacteria and other microorganisms that live in and on us. This issue features two articles about new results from this hot field. Laura Sanders details surprising ways that gut microbes can meddle with the brain, hinting that certain microbial mixes may influence depression and other mental disorders. And Meghan Rosen describes the microbiome’s role in malnutrition, suggesting that resetting children’s microbes may be a useful treatment. It’s hard not to conclude that manipulating the bacteria in your body could offer a path to better health and happiness.