A little bit of stress might be just what the doctor ordered to combat obesity and diabetes.
A new study in mice finds that a protein that plays a role in responding to certain kinds of stress may help regulate a metabolic pathway important for controlling blood sugar, burning fat and even making tumors grow. The study shows that the protein, known to play a role in aging (SN: 1/31/09, p. 13), is part of a protein family that has its finger on the pulse of both major pathways cells use to make energy, says Leonard Guarente, a molecular biologist at MIT who was not involved in the research.
The study indicates that the protein, known as sirtuin 6, or SIRT6, is what’s known as a master regulator, in this case helping cells switch between oxidative metabolism, the major form of energy production in cells; and anaerobic glycolysis, a less efficient way of making energy and can be tapped when oxygen or nutrients are in short supply. The anaerobic form of glycolysis needs more glucose to generate the same amount of energy as oxidative processes. The study, which appears in the Jan. 22 Cell, could lead the way to new therapies for diabetes and obesity.
Sirtuins are a family of proteins found in many organisms from yeast to humans. The most famous of the seven sirtuin proteins in humans, SIRT1, has been studied as a possible antiaging compound. That protein also helps regulate oxidative metabolism. Until recently, not much was known about the roles of other sirtuins.