Mapping the fruit fly brain
New digital atlas demystifies complex neuron shapes and connections
WASHINGTON — A new computer-based technique is exploring uncharted territory in the fruit fly brain with cell-by-cell detail that can be built into networks for a detailed look at how neurons work together. The research may ultimately lead to a complete master plan of the entire fly brain. Mapping the estimated 100,000 neurons in a fly brain, and seeing how they interact to control behavior, will be a powerful tool for figuring out how the billions of neurons in the human brain work.
The program has already found some new features of the fruit fly brain, said study coauthor Hanchuan Peng of the Howard Hughes Medical Institute’s Janelia Farm Research Campus in Ashburn, Va. “We can see very beautiful and very complicated patterns,” said Peng, who presented the results April 9 at the 51st Annual Drosophila Research Conference. “If you look at neurons at a better resolution, or look at regions you’ve never looked at before, you’ll find something new.”
Peng and his colleagues developed a method, also described in the April Nature Biotechnology, which incorporates many different images of fruit fly brains. The brains come from flies that were genetically programmed so that select neurons glow when struck with a particular type of laser light. By combining thousands of these digital images from different flies, the researchers can create maps of how these different neuronal populations fit together. The full map of the fly brain isn’t yet complete, but it will grow as more images are added.
These kinds of large-scale studies that focus on how neurons are connected are “very important for the future,” commented geneticist Wei Xie of Southeast University in Nanjing, China. Understanding how all of the neurons work together is much more meaningful than studying how a single brain cell connects to another cell, Xie said. “Just a neuron is not enough.”