Body’s immune protein fights breast cancer
Interleukin-25 has potential as a new therapy
By Nathan Seppa
The body’s cancer-fighting defenses include an immune protein that seems able to distinguish between normal and malignant breast cells. When confronted with a malignant cell, the protein instructs it to self-destruct, but leaves normal cells unaffected, scientists find.
This quality suggests that the protein, interleukin-25, has potential as a breast cancer treatment, says study coauthor Saori Furuta, a molecular biologist at the Lawrence Berkeley National Laboratory, in California. The report appears in the April 13 Science Translational Medicine.
Furuta and her colleagues focused on breast epithelial cells, which form part of the milk-producing mammary glands and are the cells that turn malignant in the vast majority of breast cancers. To test the role of interleukin-25, they implanted 15 mice with breast tumors and injected the tumors with either IL-25 or a saline placebo daily. After a month, the tumors in the untreated animals had tripled in size whereas tumors in the IL-25–treated mice were virtually unchanged.
IL-25 works by binding to a receptor protein embedded in the membrane of a cell. Receptors act as docking stations and, when bound, send signals to the control center, or nucleus, of the cell. When four cell lines of breast cancer grown in lab dishes were exposed to IL-25, this protein-to-receptor binding triggered destruction of malignant cells — which is apparently what happened in the mice. IL-25 had no effect on healthy breast cells.