Team locates anthrax-receptor protein
By Nathan Seppa
Scientists have identified the protein that enables the anthrax toxin to attach to cells and trigger disease. Meanwhile, other researchers have mapped the molecular structure of the toxin component that does most of the damage to cells.
The findings, slated for release in the Nov. 8 issue of Nature, were unveiled this week as infections from letter-borne anthrax spores continue to crop up across the eastern United States.
In hosts such as people and livestock, the anthrax bacterium emerges from its protective spore and begins to grow. It releases the three components of its toxin–known as lethal factor, edema factor, and protective antigen (PA) –which assemble on cell surfaces. First to attach is PA, which binds to a receptor protein on a cell. Next, PA is cleaved by an enzyme there. Then, the other two toxin components attach to PA and gain entry into the cell. Once inside, lethal factor triggers the biochemical cascade that leads to anthrax’s symptoms, which are most dangerous when the spores have been inhaled.